Detection of Aluminium at BioChem – reliable and highly accurate trace analysis

The European Pharmacopoeia requires a limit of 10 microgram/litre for aluminium in WFI (water for injection). Increased values of aluminium are in particular disadvantageous for newborns and for patients needing hemodialsysis. Subsequently, monitoring of aluminium is an essential part of pharmaceutical quality control in certain cases.
 

The problem is the trace analysis of aluminium on the one hand whilst aluminium is also one of the most ubiquitous elements on the other hand. The method of choice at BioChem is AAS (atom absorption spectroscopy) in a graphite tube. By optimizing that method via
 

• Application of a special temperature program
• Preconditioning of the surface of the graphite tube 
• Use of argon instead of nitrogen as rinsing gas
•  Application of a Zeeman rather than a deuterium compensation 
  
   
  BioChem accomplishes with its almost 25 y of experience in AAS a subtile and reliable aluminium analytics in both WFI and in any water containing matrices as well as in rather complex samples like e.g. egg lecithin. In addition, that method requires sample volumes of just about 0.5 – 1 ml.

Please, find more in our German version of this article